Home / Health Information

Health Information

According to the Soft Coated Wheaten Terrier Club of America’s Website… “The Soft Coated Wheaten Terrier is basically a healthy dog who, given proper care and nourishment, will live a long and active life. All breeds, however, are susceptible to inherited disease and the Wheaten is no exception. Veterinary research has identified two possibly genetically transmitted conditions which seem to have a higher than normal incidence in Wheatens; protein-losing nephropathy (PLN) and protein-losing enteropathy (PLE). Addison’s Disease also occurs and renal dysplasia (RD) which has been a serious problem among Wheatens in other countries and there have been some cases of the disease in the United States.”

The SCWTCA Endowment, Inc. ( www.wheatenhealthendowment.org) list an article by Meryl Littman, VMD, DACVIM from the University of Pennsylvania School of Veterinary Medicine on August 4, 2016 titled:

Recommendations Concerning Protein‐Losing Nephropathy (PLN) in Soft Coated Wheaten Terriers

PLN Testing Recommendations

Recommendations Concerning Protein‐Losing Nephropathy (PLN) in Soft Coated Wheaten Terriers*

Meryl Littman, VMD, DACVIM
Professor Emerita of Medicine (Clinician‐Educator)
University of Pennsylvania
School of Veterinary Medicine
August 4, 2016

1. I recommend having each dog’s DNA sample tested for the PLN‐associated variant alleles at Dr. Paula Henthorn’s lab at Penn Vet. The results will help you know the individual’s risk for developing PLN in its lifetime and help you with decisions about breeding partners.

a. The information about how to submit DNA samples (cytology brushes for cheek swabs, samples of whole blood or semen) is found at www.scwtca.org/health/dnatest.htm.

b. Dogs with homozygous positive genotype (2 copies) have the highest risk of developing PLN, dogs with heterozygous genotype (1 copy) have an intermediate risk, and dogs with homozygous negative genotype (no copies) had the lowest risk of developing PLN during their lifetimes. Any breed dog can develop PLN, which can be due to infectious, inflammatory, neoplastic, toxic, or genetic influences.

c. The current effort is to choose mates for dogs so as to avoid producing homozygous positive dogs. Since the allele frequency is high, culling heterozygotes is not recommended since it would lead to loss of genetic diversity in the breed and possible future (other) genetic problems. Thus, healthy dogs that are carriers of one or two copies should have mates that are homozygous negative, so that puppies will be clear or heterozygous at most.

2. Every healthy Wheaten should be screened (blood and urine tests) annually for changes that might suggest the genetic predispositions for the breed (PLN, protein‐losing enteropathy (PLE), Addison’s disease, renal dysplasia, etc). There are no genetic tests yet for these except for PLN. Dogs that are carrying one or two copies of the PLN‐associated variant alleles should be checked for proteinuria more often, perhaps 2‐4 times a year, especially after age 3 years. Dogs that are sick should have a thorough work‐up.

a. Annual recommended screening usually involves urinalysis (SG, dipstick, sediment), either microalbuminuria or urine protein/creatinine ratio (UPC), CBC (complete blood count, to check for cytopenias, eosinophilia), metabolic biochemical screen (Chemscreen, including creatinine, BUN, total protein, albumin, globulin, Na, K, Ca, Phos, glucose, ALT, Alk phos, and cholesterol), and in tickborne or heartworm endemic areas, a SNAP‐4DxPlus or AccuPlex4 test. An SDMA test is also helpful to evaluate kidney function. A ‘minimal screen’ (less expensive) might include a urine SG/dipstick, blood PCV/TS, creatinine, BUN, albumin and globulin. If any tests are abnormal, further workup is advised.

b. If proteinuria is found or suspected, interpretation must be made regarding urine pH, sediment, if the sample were taken post‐ejaculation, post‐prandial, whether the sample was obtained from home or in the clinic, and whether the dog is hypertensive or on medication that could raise blood pressure measurement (eg, phenylpropanolamine for urinary incontinence).

c. If samples are requested for UPC determination, either for screening or to monitor PLN dogs that are on treatments, because of daily variability it is suggested that 3 samples be brought in from home, collected each day (first morning sample is best) for 3 days, saved in the refrigerator, and brought to the vet so that equal aliquots (1 ml) of each sample can be mixed together and submitted as one sample, to get an averaged UPC determination. Daily variability can be as much as 80% for dogs with UPC of 0.5 and 35% for dogs with UPC of 12.0. Normal UPC is less than 0.2; borderline is 0.2‐0.4, and greater than 0.4 is abnormal.

3. When a dog has proteinuria:

a. It could be due to pre‐renal, renal, or post‐renal causes. Even if the dog is a carrier of one or two copies of the PLN‐associated variant alleles, it should not be assumed to have PLN (renal cause) and will need a work‐up, for instance to rule out urinary tract infection, tickborne/heartworm disease, neoplasia, hypertension, and consideration of other causes for PLN such as amyloidosis, lupus, shigatoxin (raw meat diet), etc.

b. Each dog’s diagnosis and management plan must be individualized. For instance, dogs with PLN should be a fed a renal diet that is modified to be lower in protein and phosphorus. But if the dog also has had food allergies, inflammatory bowel disease, PLE, pancreatitis, skin or ear issues, then the diet also needs to be lower in fat and also hypoallergenic. There are specific diets that are recommended depending on the needs of the individual. Likewise, medications such as ACE inhibitors, antihypertensives, antithrombotics, omega‐3 fatty acid supplements, antimicrobials, etc. are individualized depending on the dog’s test results and tweaked, based on monitoring over time. I have seen dogs with PLN live quality lives for much longer than in the past because we are screening for occult abnormalities and starting interventions earlier than we used to, when they can really have impact to slow the progression of disease. There are 8 recent IRIS Consensus papers concerning the diagnosis and treatment of PLN that I recommend. They are available on‐line at http://onlinelibrary.wiley.com/doi/10.1111/jvim.2013.27.issues1/issuetoc;jsessionid=55A453D9706C2FD288D76133300774F4.f04t01.

c. Since these cases can be very complicated, I recommend getting a consultation with a specialist near you who is Board Certified and a Diplomate of the American College of Veterinary Internal Medicine, with the initials ‘DACVIM’ behind their name. Your vet can recommend one or you can find one near you by going to www.acvim.org.

d. After 41 years of vetting and a wonderful 38‐year career at Penn Vet, I retired in July 2016. I am still travelling, speaking, writing, and giving on‐line advice. If you want my opinion concerning questions about Wheaten or Airedale genetic diseases (PLN, PLE, inflammatory bowel disease, food allergies, Addison’s, renal dysplasia), Lyme and other tick‐borne diseases, Leptospirosis, vaccinations, etc., or you want a consultation regarding a sick or healthy dog, you and your vet can still reach me at merylitt@vet.upenn.edu, however, my on‐line advice is no longer free. Fees for ‘fast’ questions are $25‐50 and consultations are $125‐250, depending on complexity. Since I may be travelling, I may not respond to your emails as fast as I used to.
I do hope you and your loved ones stay well so you can enjoy each other for a long, long time! Take care. ‐Meryl

 

The Soft Coated Wheaten Terrier Club of Greater Tampa Bay is registered as a charitable organization in Florida (Reg No. CH50498).

A COPY OF THE OFFICIAL REGISTRATION AND FINANCIAL INFORMATION MAY BE OBTAINED FROM THE DIVISION OF CONSUMER SERVICES BY CALLING TOLL-FREE  (800-435-7352) WITHIN THE STATE. REGISTRATION DOES NOT IMPLY ENDORSEMENT, APPROVAL OR RECOMMENDATION BY THE STATE.